Higher purity PCR products with excellent primer dimer removal
March 4, 2014

In modern science, nucleic acid purification represents the most important and critical step to the success of all molecular biology applications. Scientists are often wasting their time and money using technologies that cannot deliver the yield and purity levels that they promise, especially without adding time or cost to their application. For this reason, OmniGenX is excited to announce that the new PureMag PCR Clean Up Kits can deliver a higher purity, higher yield PCR product that doesn't increase lab's costs or processing time but actually allows the final user to save money with its 20 minute protocol.

The PureMag PCR Clean Up Kits utilize state of the art paramagnetic bead technology that combined with unique buffer formulations delivers a superior high-throughput purification of PCR amplicons greater than 60bp. Thanks to the large surface area, the advanced chemistry, and the unique paramagnetic technology, PureMag beads provide more binding sites for nucleic acids. This results in higher yields and a recovery rate of 90% - which is significantly higher than the 80% obtained from the competition. Also, uniform bead size and shape guarantee a robust and reproducible performance by reducing variations from sample to sample.

But what is really revolutionary and sets these kits apart from the other beads available on the market is that they can efficiently remove primer dimers. While all beads on the market can deliver a purified product that is essentially free of contaminants by removing unincorporated primers, dNTPs, salts and enzymes during the binding and washing steps of the protocol, PureMag beads have proven to efficiently remove primer dimers. This eliminates extra time consuming clean-up steps and reduces the potential of sequencing bias. In other words, after the easy 20 minute protocol is completed, the PureMag purified product is ready to be used in routine and downstream applications such as Sequencing, Genotyping and SNP Detection, and Cloning with no extra clean-ups required! After PureMag beads are added at a 1.8 ratio and the binding of the PCR products occurs, a magnetic plate or device can immobilize the beads in seconds. And unlike conventional methods that require centrifugation to pellet the beads and careful aspiration, a magnetic device can ensure a maximum sample recovery by allowing a complete buffer removal with no sample dilution nor bead loss.

In conclusion, after taking a close look at all the magnetic beads that are available on the market, we can say that OmniGenX PureMag beads deliver a higher quality product that is also significantly more affordable than the other beads that are available at this time for PCR Clean up and NexGen Sequencing sample prep.

Maximal recovery and purity from the lowest elution and sample volumes
March 28, 2013

DNA and RNA purifications are an integral part of many application protocols in today's life science research. OmniGenX was founded to deliver state of the art technologies that provide pure product with high yields from a variety of sources such as single cells and difficult to lyse sample sources, as well as tools that can help scientists optimize the process.

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